Two sample MR report
SIRPB1_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | -0.4336182 | 0.2657571 | 0.2443410 |
| Weighted median | 4 | -0.0823496 | 0.0349278 | 0.0183880 |
| Inverse variance weighted | 4 | -0.0643879 | 0.0284418 | 0.0235837 |
| Simple mode | 4 | -0.0816822 | 0.0492329 | 0.1956781 |
| Weighted mode | 4 | -0.0889962 | 0.0417626 | 0.1228945 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.6035169 | 2 | 0.7395167 |
| Inverse variance weighted | 2.5561818 | 3 | 0.4652233 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.2237792 | 0.1601422 | 0.2971399 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001245 | 0 | TRUE | 0.2901384 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
